Synthesis of 3,4,5,6,7,8-Hexahydro-4-aryl-8-arylidene-2(1H)-quinazolinethiones and Their Reactions with Dialkyl Chloroethynylphosphonates

Key Points

• This work aims to synthesize new quinazolinethiones and explore their reactivity with chloroethynylphosphonates.
• Synthesized hexahydroquinazolinethiones using cyclohexanone bis-chalcones and thiourea.
• Modified the resulting products with chloroethynylphosphonates to obtain new derivatives.
• Successfully synthesized a series of 3,4,5,6,7,8-hexahydroquinazolinethiones.
• Generated new phosphorylated thiazolo[2,3-b]quinazoline derivatives through successful modification.