Does the Hemodynamic Gain Index predict all-cause mortality and/or heart transplantation in patients with hypertrophic cardiomyopathy?
In patients with hypertrophic cardiomyopathy, the hemodynamic gain index correlates well with circulatory power, suggesting potential utility as a nonmetabolic exercise testing parameter.
Hemodynamic gain index (HGI) is a novel, simple parameter calculated from resting and peak systolic blood pressure and heart rate (HR) during exercise, however, its prognostic value in patients with hypertrophic cardiomyopathy (HCM) is unknown. We investigate the prognostic value of alternative nonmetabolic exercise testing parameters in a contemporary HCM cohort. HGI was calculated from systolic blood pressure at rest and peak /HR data from consecutive HCM patients who underwent cardiopulmonary exercise testing for symptom evaluation. Multivariable Cox regression analysis was performed with the primary outcome of all-cause mortality and/or heart transplantation. Logistic regression models were used for HGI to predict the need for future myectomy or alcohol septal ablation. In our cohort of 905 patients with HCM, HGI correlated well with circulatory power (CP, r = 0.71, p <0.001) and peak VO
Vanhentenrijk et al. (Fri,) studied this question.