Key result
Hemodynamic gain index strongly correlates with circulatory power in patients with hypertrophic cardiomyopathy.
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Why the study?
The prognostic value of the hemodynamic gain index in patients with hypertrophic cardiomyopathy was unknown.
Does the Hemodynamic Gain Index predict all-cause mortality and/or heart transplantation in patients with hypertrophic cardiomyopathy?
Cohort (n=905)
Does the Hemodynamic Gain Index predict all-cause mortality and/or heart transplantation in patients with hypertrophic cardiomyopathy?
In patients with hypertrophic cardiomyopathy, the hemodynamic gain index correlates well with circulatory power, suggesting potential utility as a nonmetabolic exercise testing parameter.
HGI may serve as a noninvasive correlate of circulatory power in HCM; leaves open its independent prognostic value pending validation.
Hemodynamic gain index (HGI) is a novel, simple parameter calculated from resting and peak systolic blood pressure and heart rate (HR) during exercise, however, its prognostic value in patients with hypertrophic cardiomyopathy (HCM) is unknown. We investigate the prognostic value of alternative nonmetabolic exercise testing parameters in a contemporary HCM cohort. HGI was calculated from systolic blood pressure at rest and peak /HR data from consecutive HCM patients who underwent cardiopulmonary exercise testing for symptom evaluation. Multivariable Cox regression analysis was performed with the primary outcome of all-cause mortality and/or heart transplantation. Logistic regression models were used for HGI to predict the need for future myectomy or alcohol septal ablation. In our cohort of 905 patients with HCM, HGI correlated well with circulatory power (CP, r = 0.71, p <0.001) and peak VO
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Vanhentenrijk et al. (2026) conducted a cohort in Hypertrophic Cardiomyopathy (n=905). Hemodynamic gain index (HGI) was evaluated on All-cause mortality and/or heart transplantation. In patients with hypertrophic cardiomyopathy, the hemodynamic gain index correlated well with circulatory power (r = 0.71, p <0.001).
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