Integrated cascade catalysis of AuPtCu nanozymes and glycolysis inhibition for synergistic breast cancer therapy via metabolism regulation

Key Points

• This research aims to explore a synergistic therapeutic strategy using integrated cascade catalysis and metabolism regulation to combat breast cancer.
• Utilized a 4T1 tumor-bearing mouse model to evaluate treatment efficacy.
• Applied multimetallic nanozymes for catalysis alongside glycolysis inhibition strategies.
• Monitored tumor growth, pulmonary metastasis, and hypoxia levels in response to treatment.
• The synergistic therapy significantly inhibited tumor growth compared to control groups.
• There was a marked reduction in pulmonary metastasis.
• Sustained oxidative stress was achieved while alleviating hypoxia.