Integrated cascade catalysis of AuPtCu nanozymes and glycolysis inhibition for synergistic breast cancer therapy via metabolism regulation

Q: What does this research mean for the field?

A synergistic strategy combining integrated cascade catalysis of AuPtCu nanozymes and glycolysis inhibition effectively inhibits tumor growth, suppresses pulmonary metastasis, and alleviates hypoxia in breast cancer. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Kanglong Wang; Cheng Ni; Junhao Huang; Yunfei Huang; Xueyan Cao; Jing Ma; Xiangyang Shi; Rui Guo

doi:10.1039/d6bm00208k

January 1, 2026Biomaterials Science

Integrated cascade catalysis of AuPtCu nanozymes and glycolysis inhibition for synergistic breast cancer therapy via metabolism regulation

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Key Points

This research aims to explore a synergistic therapeutic strategy using integrated cascade catalysis and metabolism regulation to combat breast cancer.
Utilized a 4T1 tumor-bearing mouse model to evaluate treatment efficacy.
Applied multimetallic nanozymes for catalysis alongside glycolysis inhibition strategies.
Monitored tumor growth, pulmonary metastasis, and hypoxia levels in response to treatment.
The synergistic therapy significantly inhibited tumor growth compared to control groups.
There was a marked reduction in pulmonary metastasis.
Sustained oxidative stress was achieved while alleviating hypoxia.

Implication

Shows synergistic tumor growth inhibition in a breast cancer model, indicating enhanced therapeutic potential.

Abstract

studies in a 4T1 tumor-bearing mouse model confirmed that this synergistic strategy of metabolic starvation and sustained oxidative stress could effectively inhibit tumor growth and suppress pulmonary metastasis, while alleviating hypoxia. This work provides a versatile framework for the design of multimetallic nanozymes and multi-pathway synergistic strategies for advanced cancer therapy.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a0d50cdf03e14405aa9ceec https://doi.org/10.1039/d6bm00208k

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Integrated cascade catalysis of AuPtCu nanozymes and glycolysis inhibition for synergistic breast cancer therapy via metabolism regulation

Key Points

Implication

Abstract

Discussion

Cite This Study

Integrated cascade catalysis of AuPtCu nanozymes and glycolysis inhibition for synergistic breast cancer therapy via metabolism regulation

Key Points

Implication

Abstract

Discussion

Cite This Study

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