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October 17, 2025Advanced ScienceOpen Access

Bimetallic Nanozyme Amplifier for Synergistic Ferroptosis‐Cuproptosis and Metabolic Reprogramming to Reshape Immunosuppressive Tumor Microenvironment

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Authors

JLJianzhang LuoGuilin Medical UniversityKHKunzhao HuangGuilin Medical UniversityXYXiaoyuan YiGuilin Medical University

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Implication

Engineered nanoparticles improve immunogenic cell death and reshape the tumor microenvironment, suggesting new HCC therapies.

Key Points

  • The platform induces significant metabolic reprogramming, enhancing both ferroptotic and cuproptotic processes.
  • Dendritic cells maturation is promoted, restoring functionality in CD4⁺/CD8⁺ T-cells within the tumor microenvironment.
  • By reducing lactate levels and increasing glucose availability, the approach alters the immunosuppressive tumor microenvironment.
  • This multimodal strategy integrates cell death modulation with metabolic regulation, potentially advancing hepatocellular carcinoma treatment.

Cite This Study

Luo et al. (2025) studied this question.

synapsesocial.com/papers/68f199d1de32064e504dd6a8https://doi.org/10.1002/advs.202512764
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Convergence of Sonodynamic Therapy and Cuproptosis in the Dual-Responsive Biomimetic CytoNano for Precision Mitochondrial Intervention in Cancer Treatment2024 · 32 citations
  2. 2Cuproptosis: mechanisms and links with cancers2023 · 826 citations
  3. 3Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy2020 · 2,571 citations
  4. 4Ferroptosis: mechanisms and links with diseases2021 · 1,498 citations
  5. 5Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives2024 · 237 citations