Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 11, 2025Advanced Functional Materials

A Responsive Hydrogel Containing Bimetallic MOF Enabling Amplified Ferroptosis for Cancer Therapy via Dual Cellular Homeostasis Disruption

View Full Paper
Ask AI
Bookmark
Share

Authors

MWMiao WangShanghai Jiao Tong UniversityQCQian ChenDalian UniversityZCZ.‐Y. Cheng

Discussion

Loading...

Member takes

Overview

Innovative dual cellular homeostasis disruption amplifies ferroptosis in tumor cells, indicating enhanced treatment potential.

Key Points

  • Amplifying ferroptosis leads to improved cancer cell death through dual homeostasis disruption strategies.
  • The key metric reveals enhanced ferroptotic response in tumor models, highlighting the significance of p53 pathway activation.
  • The approach uses a pH/ROS responsive hydrogel containing bimetallic MOF and autophagy inducers for efficacy.
  • This method suggests potential avenues for overcoming limitations in existing ferroptosis-based cancer therapies.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68a360ce0a429f7973328c84https://doi.org/10.1002/adfm.202502635
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A redox homeostasis disruptor based on a biodegradable nanoplatform for ultrasound (US) imaging-guided high-performance ferroptosis therapy of tumors2024 · 1 citations
  2. 2Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy2020 · 165 citations
  3. 3Hypoxia nanoalleviator with dual disruption of iron and redox metabolism for efficient ferroptosis-mediated cancer immunotherapy2026 · 1 citations
  4. 4Metal-organic framework-based fuel-driven chemical reaction network for ferroptosis therapy2026
  5. 5Ferroptosis: A new horizon in cancer therapy2025 · 6 citations