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July 1, 2026Journal of NanobiotechnologyOpen Access

Metal-organic framework-based fuel-driven chemical reaction network for ferroptosis therapy

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Authors

DGDing GuoQLQian LinQJQuanyi Jin

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Overview

Randomized trial demonstrates enhanced tumor growth inhibition in cancer cells, suggesting a new cancer treatment method.

Key Points

  • This research aims to enhance the efficacy of ferroptosis therapy by developing a novel drug delivery system to overcome ferroptosis defense pathways.
  • Designed a drug delivery system (SRF@Au@M NPs) based on MIL-100(Fe) for targeted tumor cell action.
  • Initiated a chemical reaction network (CRN) to trigger ferroptosis by disintegrating under high GSH concentrations and releasing sorafenib.
  • Conducted in vivo tests to evaluate tumor growth inhibition in tumor-bearing mice.
  • Achieved 92.5% tumor growth inhibition in 4T1 tumor cells compared to control groups.
  • Confirmed significant activation of ferroptosis through continuous reactive oxygen species generation.
  • Effectively disrupted multiple ferroptosis defense pathways, enhancing therapeutic response.

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/6a44af055cd2549c8bc4427fhttps://doi.org/10.1186/s12951-026-04718-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  4. 4A Responsive Hydrogel Containing Bimetallic MOF Enabling Amplified Ferroptosis for Cancer Therapy via Dual Cellular Homeostasis Disruption2025 · 16 citations
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