July 15, 1995Circulation

Mineralocorticoid receptor is coexpressed with 11-HSD in the human heart, with cardiac 11-HSD activity detected at 243 +/- 26 fmol/30 min/mg protein, enabling direct aldosterone action.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Cardiac surgery patients and heart transplant recipients. Primary outcome: Expression of mineralocorticoid receptor (MR) and 11-HSD catalytic activity.

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Key result

Mineralocorticoid receptor is coexpressed with 11-HSD in the human heart, with cardiac 11-HSD activity detected at 243 +/- 26 fmol/30 min/mg protein, enabling direct aldosterone action.

Authors

MLMarc Lombès NANadia Alfaidy EEEmmanuel Eugène

Discussion

Member takes

Overview

May support direct cardiac aldosterone effects in humans; leaves open clinical relevance for MR antagonists beyond renal actions.

Study Design

Type

Observational

PICO

Population

Cardiac surgery patients and heart transplant recipients

Primary Outcome

Expression of mineralocorticoid receptor (MR) and 11-HSD catalytic activity

Cite This Study

Lombès et al. (1995) conducted an observational in Cardiac surgery patients and heart transplant recipients. Mineralocorticoid receptor is coexpressed with 11-HSD in the human heart, with cardiac 11-HSD activity detected at 243 +/- 26 fmol/30 min/mg protein, enabling direct aldosterone action.

synapsesocial.com/papers/6a0ed0f5c12540356222b195 https://doi.org/10.1161/01.cir.92.2.175

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July 15, 1995Circulation

Mineralocorticoid receptor is coexpressed with 11-HSD in the human heart, with cardiac 11-HSD activity detected at 243 +/- 26 fmol/30 min/mg protein, enabling direct aldosterone action.

View Full Paper

Ask AI

Bookmark

Key result

Mineralocorticoid receptor is coexpressed with 11-HSD in the human heart, with cardiac 11-HSD activity detected at 243 +/- 26 fmol/30 min/mg protein, enabling direct aldosterone action.

Authors

MLMarc Lombès NANadia Alfaidy EEEmmanuel Eugène

Discussion

Member takes

Overview

May support direct cardiac aldosterone effects in humans; leaves open clinical relevance for MR antagonists beyond renal actions.

Study Design

Type

Observational

PICO

Population

Cardiac surgery patients and heart transplant recipients

Primary Outcome

Expression of mineralocorticoid receptor (MR) and 11-HSD catalytic activity

Cite This Study

synapsesocial.com/papers/6a0ed0f5c12540356222b195 https://doi.org/10.1161/01.cir.92.2.175

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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