What question did this study set out to answer?

This study aims to clarify the contributions of arterial and ventricular pressures versus circulating angiotensin II and aldosterone in hypertrophy and collagen buildup in hypertension.

December 1, 1990Circulation Research

Remodeling of the rat right and left ventricles in experimental hypertension.

View Full Paper

Ask AI

Bookmark

Authors

CBChristian G. BrillaUniversitätsklinikum Tübingen RPR PickDuPont (United States)LTLip Bun TanMonash Health

Discussion

Member takes

Implication

Randomized trial examines collagen accumulation in ventricles under different hypertension models, suggesting distinct regulatory mechanisms.

Key Points

This study aims to clarify the contributions of arterial and ventricular pressures versus circulating angiotensin II and aldosterone in hypertrophy and collagen buildup in hypertension.
Examined three models of experimental hypertension with varying angiotensin II and aldosterone profiles: renovascular hypertension, infrarenal aorta banding, and chronic AL infusion.
Compared effects on left and right ventricular remodeling and collagen accumulation among groups.
In renovascular hypertension, significant increases in interstitial collagen volume fraction and perivascular collagen area in both left and right ventricles were observed.
Infrarenal aorta banding did not induce similar remodeling despite comparable systemic hypertension and left ventricular hypertrophy.

Cite This Study

Brilla et al. (1990) studied this question.

synapsesocial.com/papers/6a0873c0ab15ea61dee8db2f https://doi.org/10.1161/01.res.67.6.1355

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial examines collagen accumulation in ventricles under different hypertension models, suggesting distinct regulatory mechanisms.

Remodeling of the rat right and left ventricles in experimental hypertension.

Discussion

Member takes

Implication

Key Points

Cite This Study

Remodeling of the rat right and left ventricles in experimental hypertension.

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider