Why the study?
Do spironolactone and losartan reduce myocardial fibrosis in a rat model of renovascular hypertension?
Population
Goldblatt model of two-kidney, one clip hypertension in the rat
Comparison
Spironolactone or losartan vs Untreated two-kidney, one clip hypertensive rats
Design
Preclinical
Authors
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Should not change clinical practice; leaves open collagen subtype-specific targeting in human hypertension.
Do spironolactone and losartan reduce myocardial fibrosis in a rat model of renovascular hypertension?
Angiotensin II and aldosterone independently mediate different types of myocardial collagen deposition in renovascular hypertension, with angiotensin II driving type I and aldosterone driving type III collagen.
Nicoletti et al. (1995) studied this question.
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