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January 1, 1997Journal of Hypertension

Renin-angiotensin system and myocardial collagen matrix

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Why the study?

Does Angiotensin II stimulate collagen synthesis and increase intracellular Ca2+ in cultured adult rat cardiac fibroblasts?

Population

Cultured adult rat cardiac fibroblasts

Comparison

Angiotensin II with or without specific Ang II… vs Control or Ang II with receptor antagonists

Design

Preclinical

Follow-up

24 hours

Authors

CBChristian G. BrillaCSChristian ScheerHRHeinz Rupp

Discussion

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Overview

May promote myocardial fibrosis via AT1-Ca2+ signaling in hypertension; leaves open translation from rat fibroblasts to human disease.

Structured PICO

Does Angiotensin II stimulate collagen synthesis and increase intracellular Ca2+ in cultured adult rat cardiac fibroblasts?

P
Population
Cultured adult rat cardiac fibroblasts
I
Intervention
Angiotensin II (Ang II) with or without specific Ang II type 1 (candesartan) or type 2 receptor antagonists for 24 hours
C
Comparator
Control (no Ang II) or Ang II with receptor antagonists
O
Outcome
Total collagen synthesis, type I collagen mRNA expression, and intracellular Ca2+ transientssurrogate

Angiotensin II directly stimulates collagen synthesis in cardiac fibroblasts via AT1 receptors and calcium signaling, providing a mechanism for myocardial fibrosis in hypertensive heart disease.

Cite This Study

Brilla et al. (1997) studied this question.

synapsesocial.com/papers/6a90ef39d2f2d69b3a7451d2https://doi.org/10.1097/00004872-199715066-00004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hormonal regulation of cardiac fibroblast function1995 · 98 citations
  2. 2Induction of cardiac fibrosis by angiotensin II2000 · 82 citations
  3. 3Antagonism of the renin-angiotensin-aldosterone system and collagenmetabolism in cardiac fibroblasts1999 · 40 citations
  4. 4Characterization of angiotensin II receptors in cultured adult rat cardiac fibroblasts. Coupling to signaling systems and gene expression.1994 · 245 citations
  5. 5Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors2001 · 93 citations