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January 1, 2000Methods and Findings in Experimental and Clinical Pharmacology

Induction of cardiac fibrosis by angiotensin II

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Population

Cultured cardiac fibroblasts from normal male adult rats (passage 2)

Comparison

Angiotensin II incubated for 24 h, with or… vs Basal cardiac fibroblasts or Angiotensin II alone

Design

Preclinical

Follow-up

24 h

Authors

PLP. LijnenKU LeuvenVPV. V. PetrovMoscow State University of Geodesy and CartographyRFRobert FagardPreventive Cardiology

Discussion

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Overview

Telmisartan blocks ANG II-induced collagen in vitro; leaves open translation to clinical fibrosis prevention.

Structured PICO

P
Population
Cultured cardiac fibroblasts from normal male adult rats (passage 2)
I
Intervention
Angiotensin II (10^-10 to 10^-6 M) incubated for 24 h, with or without AT1 antagonist (telmisartan) or AT2 antagonist (P-186)
C
Comparator
Basal cardiac fibroblasts (untreated) or Angiotensin II alone
O
Outcome
Collagen production and secretion assayed by [3H]-proline incorporationsurrogate

Angiotensin II induces cardiac fibrosis in vitro through AT1 receptor-mediated pathways, which can be completely blocked by telmisartan.

Cite This Study

Lijnen et al. (2000) studied this question.

synapsesocial.com/papers/6a717ec2e5469ee92be2005chttps://doi.org/10.1358/mf.2000.22.10.802287
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors2001 · 93 citations
  2. 2Effect of Telmisartan on Angiotensin II-Mediated Collagen Gel Contraction by Adult Rat Cardiac Fibroblasts2001 · 10 citations
  3. 3Antagonism of the renin-angiotensin-aldosterone system and collagenmetabolism in cardiac fibroblasts1999 · 40 citations
  4. 4Renin-angiotensin system and myocardial collagen matrix1997 · 68 citations
  5. 5Characterization of angiotensin II receptors in cultured adult rat cardiac fibroblasts. Coupling to signaling systems and gene expression.1994 · 246 citations