Why the study?
Does antagonism of the renin-angiotensin-aldosterone system reduce collagen synthesis and deposition in cardiac fibroblasts and myocardium?
Population
Cardiac fibroblasts and rat models including spontaneously hypertensive rats and post-myocardial infarction…
Design
Review
Key result
Angiotensin II stimulates collagen synthesis via AT1 receptors, while ACE inhibitors and AT1 antagonists reduce myocardial collagen deposition in animal models.
Authors
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Informs antifibrotic strategies targeting RAAS; leaves open translation from animal models to human outcomes.
Does antagonism of the renin-angiotensin-aldosterone system reduce collagen synthesis and deposition in cardiac fibroblasts and myocardium?
RAAS antagonism, specifically via ACE inhibitors and AT1 receptor blockers, reduces angiotensin II-mediated collagen synthesis and myocardial fibrosis.
Lijnen et al. (1999) conducted a review in Myocardial fibrosis. ACE inhibitors and AT1 receptor antagonists was evaluated. Angiotensin II stimulates collagen synthesis via AT1 receptors, while ACE inhibitors and AT1 antagonists reduce myocardial collagen deposition in animal models.