Key result
Incubation of adult rat cardiac fibroblasts with Angiotensin II or mineralocorticoids significantly increased collagen synthesis in a dose-dependent manner compared with untreated control cells.
Why the study?
Does Ang II or aldosterone directly stimulate collagen synthesis or inhibit MMP 1 production in adult rat cardiac fibroblasts?
Does Ang II or aldosterone directly stimulate collagen synthesis or inhibit MMP 1 production in adult rat cardiac fibroblasts?
Angiotensin II and mineralocorticoids directly stimulate collagen synthesis in adult rat cardiac fibroblasts, providing a mechanism for RAAS-mediated myocardial fibrosis.
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Supports RAAS-driven fibrosis in rat fibroblasts; leaves open human translation and therapeutic targeting.
Brilla et al. (1995) studied this question. Angiotensin II (Ang II) or Aldosterone (Aldo) vs. untreated control cells was evaluated on Collagen synthesis and MMP 1 activity. Incubation of adult rat cardiac fibroblasts with Angiotensin II or mineralocorticoids significantly increased collagen synthesis in a dose-dependent manner compared with untreated control cells.
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