The paper highlights the theoretical framework that vasodilators (like ACE inhibitors) and negative inotropic agents improve heart failure prognosis by restoring the balance between energy production and utilization.
The likelihood of an imbalance between energy production and energy utilization in the failing heart has important implications for patient management. Vasodilators and negative inotropic agents might prolong survival by improving the balance. One vasodilator class--angiotensin converting enzyme inhibitors--has had a remarkable effect on prognosis.
Arnold M. Katz (Thu,) studied this question.
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