What is the clinical evidence from this study?

Study design: Observational. Population: Mitral valve stenosis (n=15). Intervention: MR phase-shift velocity mapping. Primary outcome: Mitral and pulmonary venous flow velocity.

What does this research mean for the field?

MR phase-shift velocity mapping successfully quantifies mitral and pulmonary venous flow velocities, demonstrating a peak early diastolic mitral flow of 68 +/- 12 cm/s in healthy volunteers and correlating well with Doppler echocardiography in patients with mitral stenosis. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1991

MR Phase-Shift Velocity Mapping of Mitral and Pulmonary Venous Flow

Key Result

MR phase-shift velocity mapping successfully quantified flow velocities, demonstrating a peak early diastolic mitral flow of 68 +/- 12 cm/s in healthy volunteers.

Study Design

Type

Observational (n=15)

Structured PICO

Can MR phase-shift velocity mapping accurately measure mitral and pulmonary venous flow velocity compared to Doppler echocardiography?

Population

10 healthy volunteers and 5 patients with mitral valve stenosis

Intervention

MR phase-shift velocity mapping

Comparator

Doppler echocardiography (in patients with mitral valve stenosis)

Outcome

Mitral and pulmonary venous flow velocitysurrogate

MR phase-shift velocity mapping is a feasible noninvasive technique for evaluating time-related flow velocity patterns and quantifying mitral and pulmonary venous blood flow velocity.

Abstract

Mitral and pulmonary venous flows are important indexes in the evaluation of left ventricular diastolic function and in the assessment of mitral valve disease. We used MR phase-shift velocity mapping to measure mitral and pulmonary venous flow velocity in 10 healthy volunteers and mitral flow velocity in 5 patients with mitral valve stenosis. Normal mitral flow shows two positive peaks: one during early ventricular diastole and the other during atrial contraction. Peak mitral flow velocity (mean +/- SD) in early diastole was 68 +/- 12 cm/s and during atrial contraction 39 +/- 10 cm/s. The ratio of peak mitral flow velocity in early diastole to that during atrial contraction was 1.9 +/- 0.6. In patients with mitral valve stenosis, the initial high flow velocity persisted through diastole. Peak mitral flow velocity of patients with mitral valve stenosis correlated well with values obtained from Doppler echocardiography. Pulmonary venous flow showed two positive peaks: one during ventricular systole and the other in ventricular diastole. A small backflow during atrial contraction was noticed. Peak systolic velocity in the right lower pulmonary vein was 47 +/- 11 cm/s, peak diastolic velocity was 40 +/- 9 cm/s, and peak backflow velocity was 14 +/- 3 cm/s. Magnetic resonance velocity mapping is a noninvasive technique for the evaluation of time-related flow velocity patterns and for quantitative measurement of mitral and pulmonary venous blood flow velocity.

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