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The control of tension in skinned fibers by Mg-ATP and Ca described in previous publications has been studied at high substrate concentrations over a wide range of temperature and salt concentration. Curves of tension versus pCa shift systemically to the right as Mg-ATP increases. The maximum Ca-activated tension of a skinned fiber declines at sufficiently high substrate concentrations. This behavior is described by a generalization of the scheme given in the earlier reports.
Orentlicher et al. (Tue,) studied this question.
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