Ankle-brachial index in patients with peripheral arterial disease was significantly associated with aortic augmentation index (β=-11.5; P=.002) and subendocardial viability ratio (β=33.2; P=.036).
Cross-Sectional (n=65)
No
In patients with stable peripheral arterial disease, the severity of lower limb perfusion impairment is significantly associated with central aortic pressure augmentation and subendocardial viability ratio, suggesting a pathophysiologic link to cardiac prognosis.
Effect estimate: β -11.5 (95% CI -18.6 to -4.5)
p-value: p=.002
Peripheral arterial disease (PAD) is associated with increased cardiovascular mortality that correlates with peripheral perfusion impairment as assessed by the ankle-brachial arterial pressure index (ABI). Furthermore, PAD is associated with arterial stiffness and elevated aortic augmentation index (AIx). The purpose of this study was to investigate whether ABI impairment correlates with AIx and subendocardial viability ratio (SEVR), a measure of cardiac perfusion during diastole. AIx and SEVR were assessed by radial applanation tonometry in 65 patients with stable PAD (Rutherford stage I-III) at a tertiary referral center. AIx corrected for heart rate and SEVR were tested in a multivariate linear and logistic regression model to determine the association with ABI. Mean ABI was 0.8±0.2, AIx 31%±7%, and SEVR 141%±26%. Multiple linear regression with AIx as a dependent variable revealed that AIx was significantly negatively associated with ABI (β=-11.5; 95% confidence interval CI, -18.6 to -4.5; P=.002). Other variables that were associated with AIx were diastolic blood pressure (β=0.2; 95% CI, 0.1-0.4; P<.001), height (β=-46.2; 95% CI, -62.9 to -29.4; P<.001), body mass index (β=-0.4; 95% CI, -0.8 to -0.1; P=.023), and smoking (β=3.6; 95% CI, 0.6-6.6; P=.019). Multiple regression with SEVR as a dependent variable showed a significant correlation with ABI (β=33.2; 95% CI, 2.3-64.1; P=.036). Severity of lower limb perfusion impairment is related to central aortic pressure augmentation and to subendocardial viability ratio. This may be a potential pathophysiologic link that impacts cardiac prognosis in patients with PAD.
Mosimann et al. (Mon,) conducted a cross-sectional in Peripheral arterial disease (n=65). Ankle-brachial arterial pressure index (ABI) was evaluated on Aortic augmentation index (AIx) (β -11.5, 95% CI -18.6 to -4.5, p=.002). Ankle-brachial index in patients with peripheral arterial disease was significantly associated with aortic augmentation index (β=-11.5; P=.002) and subendocardial viability ratio (β=33.2; P=.036).