Bridging the gap in Alzheimer's therapy: strategic design and SAR evolution of coumarin-based hybrids as potent MTDLs

Key Points

• This research aims to develop coumarin-based hybrid molecules as a novel drug strategy for Alzheimer's disease.
• Focused on the design and evolution of coumarin-based hybrid molecules.
• Evaluated the multitargeting potential of these molecules for therapeutic efficacy.
• Demonstrated that coumarin-based hybrids effectively target multiple pathways involved in Alzheimer's disease.
• Showed significant improvement in cognitive function in preclinical models.