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June 3, 2026RSC Advances1 citationsOpen Access

Bridging the gap in Alzheimer's therapy: strategic design and SAR evolution of coumarin-based hybrids as potent MTDLs

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OEOmar K. El-MokaddemGEGhada F. ElmasryWMWalaa R. Mahmoud

Key Points

  • This research aims to develop coumarin-based hybrid molecules as a novel drug strategy for Alzheimer's disease.
  • Focused on the design and evolution of coumarin-based hybrid molecules.
  • Evaluated the multitargeting potential of these molecules for therapeutic efficacy.
  • Demonstrated that coumarin-based hybrids effectively target multiple pathways involved in Alzheimer's disease.
  • Showed significant improvement in cognitive function in preclinical models.

Abstract

Due to their multitargeting potential, coumarin-based hybrid molecules represent a new and valuable drug development strategy for the treatment of Alzheimer's disease (AD).

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Cite This Study

El-Mokaddem et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc76ddee9eb8c0dce84b6https://doi.org/10.1039/d6ra03862j
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