Chronic digitalization in dogs was associated with a 30% reduction in myocardial blood flow compared to no pretreatment, with acute intravenous digoxin causing a further 20% decrease.
Does acute and chronic digoxin administration reduce myocardial blood flow in a canine model?
Both acute and chronic digoxin administration significantly reduce myocardial blood flow and increase coronary vascular resistance in a canine model.
The myocardial blood flow was measured by the 133Xenon disappearance curve from the left ventricular wall following an injection of 133Xenon in the left coronary artery in 8 dogs without digoxin pretreatment and in 8 chronically digitalized dogs. The myocardial blood flow was significantly less (30%) in the digitalized dogs than in the dogs without pretreatment. In the digitalized dogs as well as in those without pretreatment an intravenous injection of digoxin resulted in a further significant decrease of the myocardial blood flow of about 20% and a significant increase of the coronary vascular resistance. The reduced myocardial blood flow both during acute and chronic digitalization is beleived to be of clinical importance.
Steiness et al. (Sat,) reported a other. Digoxin (acute and chronic digitalization) vs. No digoxin pretreatment was evaluated on Myocardial blood flow. Chronic digitalization in dogs was associated with a 30% reduction in myocardial blood flow compared to no pretreatment, with acute intravenous digoxin causing a further 20% decrease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: