Key result
Chronic digitalization in dogs was associated with a 30% reduction in myocardial blood flow compared to no pretreatment, with acute intravenous digoxin causing a further 20% decrease.
Why the study?
Does acute and chronic digoxin administration reduce myocardial blood flow in a canine model?
Does acute and chronic digoxin administration reduce myocardial blood flow in a canine model?
Both acute and chronic digoxin administration significantly reduce myocardial blood flow and increase coronary vascular resistance in a canine model.
May warrant caution extrapolating to humans; leaves open digoxin's effects on myocardial perfusion in clinical settings.
The myocardial blood flow was measured by the 133Xenon disappearance curve from the left ventricular wall following an injection of 133Xenon in the left coronary artery in 8 dogs without digoxin pretreatment and in 8 chronically digitalized dogs. The myocardial blood flow was significantly less (30%) in the digitalized dogs than in the dogs without pretreatment. In the digitalized dogs as well as in those without pretreatment an intravenous injection of digoxin resulted in a further significant decrease of the myocardial blood flow of about 20% and a significant increase of the coronary vascular resistance. The reduced myocardial blood flow both during acute and chronic digitalization is beleived to be of clinical importance.
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Steiness et al. (1978) studied this question. Digoxin (acute and chronic digitalization) vs. No digoxin pretreatment was evaluated on Myocardial blood flow. Chronic digitalization in dogs was associated with a 30% reduction in myocardial blood flow compared to no pretreatment, with acute intravenous digoxin causing a further 20% decrease.
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