Why the study?
Haemodynamic effects of digitalization during exercise in patients with vascular disease were not well characterized.
Does digitalization improve haemodynamic parameters at rest and during exercise in patients with vascular disease?
Observational (n=11)
Does digitalization improve haemodynamic parameters at rest and during exercise in patients with vascular disease?
Digitalization improves haemodynamic responses to exercise in patients with vascular disease who have impaired left ventricular function, but not in those with normal function.
Hypothesis-generating for digitalis in vascular disease with impaired LV function; should not change practice without randomized confirmation.
Haemodynamic studies at rest and during exercise before and after digitalization were carried out in 11 patients with vascular disease. Haemodynamic parameters at rest were within normal limits except for one patient, who had a cardiac index (CI) below 2.51/min/m2. During exercise 7 of the patients showed impaired left ventricular function. In the resting patients digitalization produced a significant decrease in pulmonary capillary wedge pressure (PCWP) and an increase of approximately 15% in left ventricular stroke work index (LVSWI) and total oxygen consumption. Myocardial oxygen consumption seemed unchanged as no significant changes were found in the product of mean arterial blood pressure and heart rate. After digitalization 6 of 7 patients with impaired left ventricular function showed improved haemodynamic response to exercise while the 4 patients with normal left ventricular function had an unchanged haemodynamic response.
No takes yet. Share an insight, caveat, or question.
Bille‐Brahe et al. (1980) conducted an observational in Vascular disease (n=11). Digitalis vs. Before digitalization (baseline) was evaluated on Haemodynamic changes at rest and during exercise.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: