Why the study?
Does acute digitalization with ouabain improve the hemodynamic response to exercise or prevent angina in patients with coronary artery disease?
Population
Patients with coronary artery disease (with and without exertional angina) and normal subjects
Comparison
0.5 mg of ouabain (acute digitalization) vs Baseline (before administration of ouabain)
Design
Cohort
Authors
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Does not support acute digitalization for angina prevention; leaves open the clinical value of hemodynamic gains in CAD.
Does acute digitalization with ouabain improve the hemodynamic response to exercise or prevent angina in patients with coronary artery disease?
Acute digitalization with ouabain improves ventricular performance but does not prevent angina during exercise in patients with coronary artery disease.
Parker et al. (1969) studied this question.
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