Melanoma of unknown primary: UV-driven genomics and the need for era-adjusted outcomes

Key Points

• The aim is to discuss the implications of UV-driven genomic patterns in melanoma of unknown primary.
• Commentary on findings from Lodde et al.
• Analysis of oncogenic patterns in melanoma
• Assessment of clinical outcomes related to UV exposure
• Melanoma of unknown primary displays patterns resembling those of sun-exposed melanoma.
• Implications for clinical course indicate a need for era-adjusted outcomes based on UV research.