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May 30, 2026British Journal of Dermatology

Melanoma of unknown primary: UV-driven genomics and the need for era-adjusted outcomes

Vincenzo De Giorgi Gabriella Perillo Giovanni Cecchi Federica Fazzari Biancamaria Zuccaro

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Key Points

The aim is to discuss the implications of UV-driven genomic patterns in melanoma of unknown primary.
Commentary on findings from Lodde et al.
Analysis of oncogenic patterns in melanoma
Assessment of clinical outcomes related to UV exposure
Melanoma of unknown primary displays patterns resembling those of sun-exposed melanoma.
Implications for clinical course indicate a need for era-adjusted outcomes based on UV research.

Implication

Comment examines UV-driven genomics and clinical progression in melanoma of unknown primary, suggesting era-adjusted outcomes are necessary.

Abstract

Comment on ‘Melanoma of unknown primary shows oncogenic pattern and clinical course of sun-exposed melanoma’ by Lodde et al

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Cite This Study

Giorgi et al. (2026) studied this question.

synapsesocial.com/papers/6a2115bdd499ed480b16ecd9 https://doi.org/10.1093/bjd/ljag224

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