July 18, 1975
View Full PaperAngiotensin II Stimulation of Prostaglandin Production in Cultured Human Vascular Endothelium
Structured PICO
Does angiotensin II stimulate prostaglandin E production in cultured human umbilical vein endothelial cells?
P
Population
Cultured human umbilical vein endothelial cells
I
Intervention
Angiotensin II
O
Outcome
Accumulation of immunoreactive material resembling prostaglandin Esurrogate
Angiotensin II stimulates prostaglandin E production in cultured human vascular endothelium, highlighting a potential mechanism for local control of vascular permeability and tone.
Abstract
Immunoreactive material resembling prostaglandin E accumulates in the medium of cultured human umbilical vein endothelial cells. Prodcution is inhibited by indomethacin and stimulated by angiotensin II. Prostaglandin secretion by endothelium may be important in platelet-dependent thrombotic phenomena, and in local control of vascular permeability and tone in vivo.