Why the study?
Does angiotensin II stimulate prostaglandin E production in cultured human umbilical vein endothelial cells?
Does angiotensin II stimulate prostaglandin E production in cultured human umbilical vein endothelial cells?
Angiotensin II stimulates prostaglandin E production in cultured human vascular endothelium, highlighting a potential mechanism for local control of vascular permeability and tone.
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No direct clinical implications from cell culture; leaves open in vivo relevance for vascular tone and permeability.
Immunoreactive material resembling prostaglandin E accumulates in the medium of cultured human umbilical vein endothelial cells. Prodcution is inhibited by indomethacin and stimulated by angiotensin II. Prostaglandin secretion by endothelium may be important in platelet-dependent thrombotic phenomena, and in local control of vascular permeability and tone in vivo.
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Gimbrone et al. (1975) studied this question.
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