Why the study?
Does renal artery infusion of angiotensin II stimulate prostacyclin release and lower blood pressure in dogs?
Does renal artery infusion of angiotensin II stimulate prostacyclin release and lower blood pressure in dogs?
Angiotensin II stimulates renal prostacyclin synthesis, which can act as a circulating hormone to modulate blood pressure and platelet aggregation.
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May modulate canine BP and platelet function via renal prostacyclin; leaves open translation to human disease or therapy.
Shebuski et al. (1980) studied this question.
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