Population
Vascular smooth muscle cells isolated from rat renal preglomerular arterioles
Comparison
Prostaglandins PGE2, PGI2, synthetic mimetics… vs Angiotensin II (ANG II) alone
Design
Preclinical
Authors
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Prostaglandin buffering of ANG II responses in renal cells may modulate vasoconstriction; leaves open in vivo relevance and any clinical implications.
Prostaglandins, particularly PGI2, buffer angiotensin II-mediated increases in intracellular calcium in renal preglomerular vascular smooth muscle cells, thereby modulating vasoconstriction.
Purdy et al. (1999) studied this question.
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