First-trimester pregnant patients with abnormal uterine artery Doppler velocimetry had higher estimated left ventricular filling pressure (P=0.004) compared to those with normal velocimetry.
Cross-Sectional (n=36)
Does abnormal uterine artery Doppler velocimetry in the first trimester associate with impaired maternal cardiac function or elevated cardiac biomarkers?
First-trimester pregnancies with abnormal uterine artery resistance exhibit echocardiographic signs of higher left ventricular filling pressure and potential systolic dysfunction, without significant elevations in cTnT or NT-proBNP.
p-value: p=<0.05
OBJECTIVE: To compare the maternal cardiac function and serum concentration of cardiac troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in first-trimester patients, according to uterine artery Doppler velocimetry (UADV). METHODS: This cross-sectional study included singleton pregnancies with normal UADV (n=17) and abnormal UADV (n=19). Maternal echocardiography was performed and blood samples were taken at 11-14 weeks. Echocardiographic parameters included: (a) left ventricular (LV) long axis velocities; (b) atrial size; (c) LV filling pressure; (d) the ratio of peak mitral flow velocity in early diastole and early mitral annular diastolic velocity (E/Ea ratio); and (e) the E/flow propagation velocity ratio. The maternal serum concentrations of cTnT and NT-proBNP were determined by sensitive and specific immunoassays. RESULTS: Patients with abnormal UADV had higher estimated left ventricular filling pressure (P=0.004), higher E/Ea ratio (P=0.03), higher E/flow propagation ratio (P=0.02), and lower LV long axis velocity (P=0.02) than those with normal UADV. There were no significant differences in the maternal serum concentration of cTnT or NT-proBNP. CONCLUSIONS: Patients with abnormal UADV in the first trimester have higher left ventricular filling pressure and may have left ventricular systolic dysfunction.
Prefumo et al. (Fri,) conducted a cross-sectional in Pregnancy (n=36). Abnormal uterine artery Doppler velocimetry vs. Normal uterine artery Doppler velocimetry was evaluated on Maternal cardiac function and serum concentrations of cTnT and NT-proBNP (p=<0.05). First-trimester pregnant patients with abnormal uterine artery Doppler velocimetry had higher estimated left ventricular filling pressure (P=0.004) compared to those with normal velocimetry.