Does baroreceptor denervation alter the blood pressure response to epinephrine in etherized dogs?
Baroreceptor denervation in etherized dogs elevates baseline blood pressure and reduces the pressor response to epinephrine, largely due to the higher baseline pressure.
Experiments were performed on dogs anesthetized with ether to determine the effects of denervation of the baroreceptors upon the blood pressure responses to graded doses of epinephrine. The results of these experiments show that the denervation procedures do not significantly affect the peak blood pressure attained or the duration of the rise in blood pressure resulting from doses of epinephrine. Denervation of the baroreceptors elevated the level of the control blood pressure and reduced the height of the pressor response significantly. At all but the 10.0 µg/kg dosage level the difference in the pressor response could be accounted for by the difference in the control blood pressure.
Hilton et al. (Sun,) studied this question.