What question did this study set out to answer?

To assess how baroreceptor denervation influences blood pressure responses to epinephrine in ether-anesthetized dogs.

July 1, 1956American Journal of Physiology-Legacy Content

Blood Pressure Responses to Epinephrine in the Etherized Dog, Before and After Baroreceptor Denervation

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Why the study?

Does baroreceptor denervation alter the blood pressure response to epinephrine in etherized dogs?

Population

Dogs anesthetized with ether

Comparison

Baroreceptor denervation vs Before baroreceptor denervation

Design

Preclinical

Authors

JHJames G. HiltonMarquette University RBRobert V. BrownAlcon (United States)

Discussion

Member takes

Implication

Baroreceptor denervation effects in dogs should not change practice; leaves open its modulation of epinephrine responses in humans.

Key Points

To assess how baroreceptor denervation influences blood pressure responses to epinephrine in ether-anesthetized dogs.
Conducted experiments on ether-anesthetized dogs to assess blood pressure responses to epinephrine.
Measured peak blood pressure and duration of response to different dosages of epinephrine.
Evaluated the effects of baroreceptor denervation on blood pressure control levels.
Denervation elevated baseline blood pressure levels in the dogs.
Peak pressor response to epinephrine was significantly reduced after denervation.
At doses below 10.0 µg/kg, pressor response differences were largely due to altered baseline blood pressure.

Structured PICO

Does baroreceptor denervation alter the blood pressure response to epinephrine in etherized dogs?

Population

Dogs anesthetized with ether

Intervention

Baroreceptor denervation

Comparator

Before baroreceptor denervation (within-subject control)

Outcome

Blood pressure responses to graded doses of epinephrine (peak blood pressure, duration of rise, height of pressor response)surrogate

Baroreceptor denervation in etherized dogs elevates baseline blood pressure and reduces the pressor response to epinephrine, largely due to the higher baseline pressure.

Cite This Study

Hilton et al. (1956) studied this question.

synapsesocial.com/papers/6a23a64355bd20cf6fa615d9 https://doi.org/10.1152/ajplegacy.1956.186.1.71

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Blood Pressure Responses to Epinephrine in the Etherized Dog, Before and After Baroreceptor Denervation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Blood Pressure Responses to Epinephrine in the Etherized Dog, Before and After Baroreceptor Denervation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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