What question did this study set out to answer?

This research aims to evaluate the blood pressure responses to epinephrine and norepinephrine in totally perfused dogs.

September 1, 1959American Journal of Physiology-Legacy Content

Effects of epinephrine and norepinephrine on blood pressure of totally perfused dogs

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Why the study?

What are the effects of epinephrine and norepinephrine on blood pressure in totally perfused dogs?

Population

Over 50 totally perfused dogs with the heart completely replaced by a pump capable of maintaining constant…

Comparison

Epinephrine and norepinephrine (0.5–10.0 µg/kg) vs Comparable doses of each agent; responses also…

Design

Preclinical

Authors

JKJames E. KendrickFlorida Hospital Cancer Institute

Discussion

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Implication

Caution against extrapolating dog-model responses to human vasopressor use; leaves open clinical relevance of differential blockade effects.

Key Points

This research aims to evaluate the blood pressure responses to epinephrine and norepinephrine in totally perfused dogs.
Utilized a pump to completely replace the heart in dogs.
Administered epinephrine and norepinephrine in doses of 0.5–10.0 µg/kg to over 50 animals.
Assessed responses following adrenergic blockade with Dibenzyline and sympathetic ganglionic blockade.
Epinephrine and norepinephrine produced identical blood pressure responses in magnitude and character.
Post-adrenergic blockade, epinephrine often led to a depressor response, while norepinephrine did not.
Sympathetic ganglionic blockade significantly heightened the pressure responses to both agents equally.

Structured PICO

What are the effects of epinephrine and norepinephrine on blood pressure in totally perfused dogs?

Population

Over 50 totally perfused dogs with the heart completely replaced by a pump capable of maintaining constant flow output against pressure heads up to 200 mm Hg

Intervention

Epinephrine and norepinephrine (0.5–10.0 µg/kg)

Comparator

Comparable doses of each agent; responses also evaluated following adrenergic blockade (Dibenzyline) and sympathetic ganglionic blockade

Outcome

Blood pressure responsessurrogate

In a totally perfused dog model, epinephrine and norepinephrine elicit identical pressor responses that are similarly potentiated by ganglionic blockade, though adrenergic blockade unmasks a depressor response unique to epinephrine.

Cite This Study

James E. Kendrick (1959) studied this question.

synapsesocial.com/papers/6a23a64355bd20cf6fa615d8 https://doi.org/10.1152/ajplegacy.1959.197.3.607

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Implication

Caution against extrapolating dog-model responses to human vasopressor use; leaves open clinical relevance of differential blockade effects.

Effects of epinephrine and norepinephrine on blood pressure of totally perfused dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of epinephrine and norepinephrine on blood pressure of totally perfused dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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