Incident type 2 diabetes rates were 29.2 to 39.8 per 100,000 person-years among youth aged 10-17, and 195.0 to 326.8 per 100,000 person-years among young adults aged 18-44.
Observational
Yes
The study highlights a high incidence of Type 2 diabetes among U.S. youth and young adults, with rates increasing with age and disproportionately affecting non-Hispanic Black and Hispanic populations.
Introduction and Objective: Type 2 diabetes (T2D) incidence has been increasing among youth. We estimated T2D incidence among youth (10-17 years) and young adults (18-44 years) using multiple networks of electronic health records (EHRs). Methods: The DiCAYA network includes six health systems/networks (HS) and two geographic centers in the United States. Incident T2D was identified in HS and geographic center EHRs leveraging a common data model and using first-time ICD-10 diagnosis codes in 2018-2023. Rates were calculated by age, sex, race/ethnicity, and site type. Results: Among youth aged 10-17, T2D incidence rates were 29.2 and 39.8 per 100,000 persons per year for geographic centers and HS, respectively (Table). Rates increased with age, were higher among females, and were highest among non-Hispanic Black and Hispanic youth. Among young adults aged 18-44, T2D incidence rates were 195.0 and 326.8 per 100,000 persons per year for geographic centers and HS, respectively. Patterns by age and race/ethnicity were similar to those in youth. Sex-specific patterns differed, with female rates higher in geographic centers but male rates higher in HS. Conclusion: T2D incidence rates exhibited similar patterns by age and race/ethnicity in youth and young adults. While the magnitude of rates varied by type of EHR network, findings are consistent with prior evidence of high T2D incidence in U.S. youth. Disclosure M. Mefford: Research Support; Current; Merck Current; Novo Nordisk, Lilly, Sanofi, Amgen Inc., Bayer AG. H.S. Gordon: None. J. Divers: None. L. Thorpe: None. R. Anthopolos: None. D.C. Lee: None. A.D. Liese: None. C. Rudisill: None. I. Zaganjor: None. M. Pavkov: None. K. Reynolds: Research Support; Ended; Merck U18DP006512 to University of Florida; U18DP006509 to Geisinger; U18DP006500 to Indiana University and Purdue University at Indianapolis; U18DP006513 to University of South Carolina; U18DP006506 to Kaiser Foundation Hospitals; U18DP006693 and U18DP006694 to Lurie Children’s Hospital; U18DP006517 to University of Colorado Component-A; U18DP006518 to University of Colorado Component-B; and U18DP006510 to New York University Long Island School of Medicine).
Mefford et al. (Fri,) conducted a observational in Type 2 diabetes. Demographic factors (age, sex, race/ethnicity) was evaluated on Incident type 2 diabetes per 100,000 persons per year. Incident type 2 diabetes rates were 29.2 to 39.8 per 100,000 person-years among youth aged 10-17, and 195.0 to 326.8 per 100,000 person-years among young adults aged 18-44.