Myocardial interstitial edema (EVF of 3.5 vs 2.9 in controls) produced an approximately 30% reduction in the heart's ability to maintain cardiac output in dogs.
Does myocardial interstitial edema compromise cardiac function and potentiate interstitial fibrosis in canine models?
Myocardial interstitial edema compromises cardiac function and is associated with increased interstitial fibrosis in canine models of hypertension and heart failure.
Absolute Event Rate: 3.45% vs 2.9%
We hypothesized that both acute and chronic accumulation of myocardial interstitial edema (extravascular fluid EVF) would compromise cardiac function. We also postulated that excess fluid within the myocardial interstitial space would potentiate interstitial fibrosis, thus further compromising function. Dogs were divided into three groups: 1) control, 2) chronic pulmonary hypertensive with right heart failure, and 3) chronic arterial hypertensive. The quantity of EVF, expressed as the unitless blood-free (wet weight-dry weight)/dry weight ratio, and interstitial fibrosis (collagen content) were determined and correlated with cardiac function at baseline and after acute elevation of coronary venous pressure and reduction of cardiac lymph flow. Control EVF was 2.90 +/- 0.20 (mean +/- SD), which increased to 3.45 +/- 0.16 after acute (3-hour) elevation of coronary sinus pressure. This EVF significantly compromised cardiac function. The EVF in chronically hypertensive dogs and in dogs with chronic right heart pressure elevations was 3.50 +/- 0.30 and 3.50 +/- 0.08, respectively. End-diastolic left ventricular interstitial fluid pressure increased from a control value of 14.9 +/- 3.1 (at EVF = 2.9) to 24.8 +/- 3.7 (at EVF = 3.5). An EVF of 3.5 produced approximately 30% reduction of the heart's ability to maintain cardiac output at a left atrial pressure of 15 mm Hg. The compromised function in these chronic models is exacerbated after acute elevation of coronary venous pressure and reduction of cardiac lymph flow. Collagen levels were elevated by at least 20% in the chronic hypertensive dogs and in the nonhypertrophied left ventricles of dogs with chronic right heart pressure elevation.(ABSTRACT TRUNCATED AT 250 WORDS)
Laine et al. (Sat,) conducted a other in Myocardial interstitial edema. Myocardial interstitial edema (acute and chronic) vs. Control was evaluated on Extravascular fluid (EVF) ratio. Myocardial interstitial edema (EVF of 3.5 vs 2.9 in controls) produced an approximately 30% reduction in the heart's ability to maintain cardiac output in dogs.