Endothelium-derived relaxing factor, bovine retractor penis muscle inhibitory factor, and sodium nitroprusside all significantly inhibited in vitro human platelet aggregation induced by collagen or U46619.
Does endothelium-derived relaxing factor (EDRF) inhibit in vitro platelet aggregation?
EDRF and other guanylate cyclase stimulants inhibit platelet aggregation in vitro, suggesting a potential role for EDRF in haemostasis.
p-value: p=<0.001
We studied the effects of endothelium-derived relaxing factor (EDRF), bovine retractor penis muscle inhibitory factor and sodium nitroprusside, three stimulants of guanylate cyclase, on the in vitro aggregation of washed human platelets. Platelet aggregation induced either by collagen or by the thromboxane A2 analogue U46619 was inhibited by all three agents. The anti-aggregatory effect of each agent was inhibited by haemoglobin. The anti-aggregatory effect of EDRF was potentiated by superoxide dismutase. These findings are discussed in relation to a potential role for EDRF in haemostasis.
Furlong et al. (Wed,) reported a other. Endothelium-derived relaxing factor (EDRF), bovine retractor penis muscle inhibitory factor, and sodium nitroprusside vs. Control (absence of these agents or presence of hemoglobin) was evaluated on In vitro platelet aggregation induced by collagen or U46619 (rate and extent) (p=<0.001). Endothelium-derived relaxing factor, bovine retractor penis muscle inhibitory factor, and sodium nitroprusside all significantly inhibited in vitro human platelet aggregation induced by collagen or U46619.