Figure S1 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression | Synapse
Figure S1 from Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor–Stroma Ratio and Promote Cancer Progression
Key Points
MAIN FINDING: Tumor-derived apolipoprotein E significantly influences the tumor-stroma ratio in pancreatic neuroendocrine tumors.
KEY EVIDENCE: A strong correlation exists between apolipoprotein E levels and the presence of a stroma-rich environment in tumors.
APPROACH: The research utilized cellular models to assess the effects of apolipoprotein E on endothelial cells within tumors.
SIGNIFICANCE: Understanding apolipoprotein E's role offers insights into cancer progression and potential therapeutic targets.
Abstract
Tumor-derived ApoE correlated with the stroma-rich environment