June 27, 2025

Formulation and Evaluation of gastro retentive Tablet of verapamil

Key Points

Batch F-6 with Crospovidone released 99% of Empagliflozin within 30 minutes, demonstrating superior performance.
The addition of superdisintegrants clearly enhanced the disintegration and drug release profiles of the tablets.
Using UV spectrophotometry for analysis ensured accurate measurement of drug release during evaluation.
This formulation method may enable improved drug delivery while maintaining pharmacopeial standards for quality.

Abstract

This study developed and evaluated mouth disintegrating tablets (MDTs) of Empagliflozin to enhance patient compliance and rapid drug onset. Using UV spectrophotometry (λmax 225nm in 0.1NHCl), MDTs were prepared via direct compression with superdisintegrants SSG, Crospovidone, and Croscarmellose sodium. All formulations met pharmacopeial standards. Batch F-6 with Crospovidone showed the best performance, releasing 99% of the drug within 30 minutes. The findings confirm the effectiveness of a minimal-excipient, direct compression method for efficient Empagliflozin delivery.

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Cite This Study

Shilpa et al. (Fri,) studied this question.

synapsesocial.com/papers/68af6210ad7bf08b1eae3296 https://doi.org/https://doi.org/10.30904/j.ijrpls.2025.4841

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