Figure S12 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• HER2.CAR T-cells showed improved cell persistence compared to B7-H3.CAR T-cells against EPN cells, enhancing therapeutic potential.
• The effectiveness of CAR T-cells against ependymomas is limited by tumor size and the overall immune response within the tumor environment.
• Studies indicate that tumor size affects CAR T-cell activity, potentially reducing their efficacy in larger tumors, a concern for treating ependymomas.
• Improving CAR T-cell expansion and persistence is crucial for combating ependymomas, particularly in the context of immune suppression.