Supplemental Table S7 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Key Points

• Cytotoxic nk cells are shown to impede response to checkpoint immunotherapy in melanoma patients, particularly with an immune-excluded phenotype.
• Key findings include marker genes associated with immune clusters of myeloid and CD8+T/NK cells in the analysis of unsupervised Louvain clustering.
• The methodology utilized unsupervised Louvain clustering combined with subclustering techniques to assess immune cell populations.
• These findings highlight the need for further investigation into the role of nk cells in immunotherapy effectiveness and patient outcomes.