Supplemental Table S7 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Joanna Poźniak; Niccolò Roda; Ewout Landeloos; Asier Antoranz; Yannick Van Herck; Amber De Visscher; Philip Georg Demaerel; Lukas Vanwynsberghe; Jeroen Declercq; Christos Gkemisis; Greet Bervoets; No‐Joon Song; Ayse Bassez; Robin Browaeys; Lotte Pollaris; Francesca M. Bosisio; Veerle Boecxstaens; Yvan Saeys; Diether Lambrechts; Zihai Li; Patrick Matthys; Oliver Bechter; Jean‐Christophe Marine

doi:10.1158/2159-8290.30050715

Key Points

Cytotoxic nk cells are shown to impede response to checkpoint immunotherapy in melanoma patients, particularly with an immune-excluded phenotype.
Key findings include marker genes associated with immune clusters of myeloid and CD8+T/NK cells in the analysis of unsupervised Louvain clustering.
The methodology utilized unsupervised Louvain clustering combined with subclustering techniques to assess immune cell populations.
These findings highlight the need for further investigation into the role of nk cells in immunotherapy effectiveness and patient outcomes.

Implication

Analysis reveals marker genes in immune clusters from melanoma patients, suggesting NK cells affect immunotherapy outcomes.

Abstract

Discriminatory marker genes of all immune clusters obtained by summarising unsupervised Louvain clustering and subclustering of myeloid, and CD8+T/NK cells.

Discussion

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Cite This Study

Poźniak et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a061490e https://doi.org/10.1158/2159-8290.30050715

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Supplemental Table S7 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplemental Table S7 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Key Points

Implication

Abstract

Discussion

Cite This Study

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