Supplemental Table S7 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype | Synapse
September 10, 2025
Supplemental Table S7 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype
Key Points
Cytotoxic nk cells are shown to impede response to checkpoint immunotherapy in melanoma patients, particularly with an immune-excluded phenotype.
Key findings include marker genes associated with immune clusters of myeloid and CD8+T/NK cells in the analysis of unsupervised Louvain clustering.
The methodology utilized unsupervised Louvain clustering combined with subclustering techniques to assess immune cell populations.
These findings highlight the need for further investigation into the role of nk cells in immunotherapy effectiveness and patient outcomes.
Abstract
Discriminatory marker genes of all immune clusters obtained by summarising unsupervised Louvain clustering and subclustering of myeloid, and CD8+T/NK cells.