Figure S19 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma | Synapse
September 10, 2025Open Access
Figure S19 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Key Points
TGFβ signaling was significantly decreased in tumors receiving RER compared to those treated with only radiation therapy.
The combination of TGFβ inhibition and radiation therapy enhanced immune cell infiltration within the tumors.
Observed reductions in metastases were linked to the combined treatment approach, indicating potential therapeutic benefits.
This study utilizes a mouse model to investigate the effects of TGFβ inhibition in Ewing sarcoma during radiation therapy.
Abstract
Figure S19. TGFβ signaling is decreased in tumors of mice that receive RER following radiation therapy as compared to mice that are treated with radiation therapy (RT) alone.