Figure S8 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

• Metastases decreased in Ewing sarcoma tumors treated with TGFβ inhibition, improving treatment efficacy.
• Immune cell infiltration increased significantly, indicating a stronger immune response to the tumors.
• Ewing sarcoma tumors in hu-CD34+ mice showed upregulation of ECM pathways, reflecting changes in tumor microenvironment.
• Findings suggest potential therapeutic implications of TGFβ inhibition for better outcomes in Ewing sarcoma patients.