September 17, 2025

Investigating Abnormal Glymphatic Function and Perivascular Space in Alzheimer’s Disease Using Dynamic Contrast-Enhanced MRI and DTI-ALPS

Key Points

Weak glymphatic function was identified in the Alzheimer's group compared to wild-type.
The study found a significant association between glymphatic function and perivascular space in AD models.
Dynamic contrast-enhanced MRI and diffusion tensor imaging were utilized to explore this relationship.
The findings may help clarify the biological mechanisms involved in Alzheimer's disease pathology.

Abstract

Motivation: The correlation between glymphatic function and perivascular space (PVS) remains unclear in Alzheimer's disease (AD). Goal(s): To investigate the relationship between glymphatic function and PVS in AD animal model. Approach: Dynamic contrast-enhanced MRI (DCE-MRI) and diffusion tensor imaging (DTI) were used to investigate the difference of perfusion function and PVS between wild-type (WT) and AD group. Results: Larger ratio of DTI-ALPS and weaker glymphatic function were found in AD group. Impact: This study reveals the relationship between glymphatic function and PVS in AD animal model.

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Cite This Study

Liang et al. (Tue,) studied this question.

synapsesocial.com/papers/68d45b0b31b076d99fa5cf70 https://doi.org/https://doi.org/10.58530/2025/3656

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