Analysis reveals a weak glymphatic function and altered perivascular space in Alzheimer's disease model, suggesting potential implications for understanding pathology.
Motivation: The correlation between glymphatic function and perivascular space (PVS) remains unclear in Alzheimer's disease (AD). Goal(s): To investigate the relationship between glymphatic function and PVS in AD animal model. Approach: Dynamic contrast-enhanced MRI (DCE-MRI) and diffusion tensor imaging (DTI) were used to investigate the difference of perfusion function and PVS between wild-type (WT) and AD group. Results: Larger ratio of DTI-ALPS and weaker glymphatic function were found in AD group. Impact: This study reveals the relationship between glymphatic function and PVS in AD animal model.
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Liang et al. (2025) studied this question.
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