What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Chronic Liver Disease: Comparison of 4D Flow to 2D Flow MRI in the Portal Vein in Healthy Volunteers and Patients

Key Points

4D flow MRI showed good consistency with 2D flow MRI, highlighting its potential for clinical use.
Velocity measurements were negatively correlated with liver stiffness in patients with significant fibrosis.
Both imaging methods effectively distinguished chronic liver disease patients from healthy volunteers.
Investigation involved 18 healthy volunteers and 55 patients, enhancing the reliability of the findings.

Abstract

Motivation: Flow parameters derived from 4D flow MRI may help detect cirrhosis and portal hypertension, but hemodynamic changes in fibrosis progression remains unclear. Goal(s): Compare 4D with standard 2D flow MRI for assessing portal hemodynamic changes in chronic liver disease (CLD) patients compared with healthy volunteers, and investigate correlations with MRE-derived liver stiffness. Approach: 18 healthy controls and 55 CLD patients underwent MRI at 3 T. Results: 4D flow MRI showed good consistency with 2D flow MRI but with a tendency of underestimation. Both flow modalities distinguished CLD patients from controls. Velocity was negatively correlated with liver stiffness in significant fibrosis and above. Impact: 4D flow MRI could serve as an alternative to 2D flow MRI for quantifying portal hemodynamics and may reflect vascular changes associated with fibrosis progression.

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Cite This Study

Cai et al. (Tue,) studied this question.

synapsesocial.com/papers/68d45b1b31b076d99fa5d452 https://doi.org/https://doi.org/10.58530/2025/1168

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