Abstract Background: Hypertension (HTN) is a major public health concern and a key risk factor for pulmonary embolism (PE), contributing substantially to cardiovascular mortality. Despite treatment advances, trends in related mortality remain underexplored. Objectives: This study examined national trends in HTN and PE-related mortality in the United States from 2000 to 2020 and assessed demographic and geographic disparities. Methods: A retrospective analysis of CDC WONDER data was performed, focusing on HTN (ICD I10-I15) and PE (ICD I26.0, I26.9, I82.8, I82.9). Joinpoint regression estimated age-adjusted mortality rates (AAMR) per 100,000 and annual percentage changes (APC). Data were stratified by year, sex, race/ethnicity, age, census region, urbanization, and state. Results: From 2000–2020, 92,181 HTN and PE-related deaths were recorded. AAMR rose from 1.3 to 3.6, with an average annual percent change (AAPC) of 4.5% (p Conclusion: HTN and PE-related mortality has risen markedly with disparities across age, sex, race, and geography, highlighting the need for equity-focused interventions.
Sajjad et al. (Tue,) studied this question.
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