Key points are not available for this paper at this time.
3D MRF with spiral projection trajectory was implemented on the 7T NexGen scanner to take advantage of its SNR benefit and state-of-the-art gradient system. To achieve high-fidelity and high-efficiency multi-parameter mapping at the mesoscale, novel techniques were developed to overcome several technical challenges in performing this acquisition, including spiral residual gradient compensation, trajectory measurement, water-only excitation RF pulse, B0 correction, B1+ correction and frequency response correction. The proposed technical developments enabled high-quality whole-brain T1, T2, and proton density mapping at 1-mm isotropic resolution in 1 minute, and 560mm isotropic resolution in 4-minutes scan time.
Cao et al. (Wed,) studied this question.